CDK1-FOXO1: A mitotic signal takes center stage in post-mitotic neurons
نویسندگان
چکیده
منابع مشابه
Mitotic Motors: Kinesin-5 Takes a Brake
A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
متن کاملCRISPR/Cas9-Mediated Gene Knock-Down in Post-Mitotic Neurons
The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for genome editing in eukaryotic cells. This technique allows for sequence-specific induction of double-strand breaks in genomic DNA of individual cells, effectively resulting in knock-out of targeted genes. It thus promises to be an ideal candidate for application in neuroscience where constitutive genetic modificatio...
متن کاملLeukemia takes center (late) stage.
on the activated platelets can bind PSGL-1, strengthening the association between the activated neutrophil microparticle and the platelets. It has been previously established that GPIb directly binds activated leukocyte Mac-1,5 as well as P-selectin expressed on activated platelets/endothelial cells,3,6 enabling GPIb -mediated plateletleukocyte-endothelial cell crosstalk; for example, platelets...
متن کاملDrosophila Wee1 Kinase Regulates Cdk1 and Mitotic Entry during Embryogenesis
Cyclin-dependent kinases (Cdks) are the central regulators of the cell division cycle. Inhibitors of Cdks ensure proper coordination of cell cycle events and help regulate cell proliferation in the context of tissues and organs. Wee1 homologs phosphorylate a conserved tyrosine to inhibit the mitotic cyclin-dependent kinase Cdk1. Loss of Wee1 function in fission or budding yeast causes premature...
متن کاملCancer epigenetics takes center stage.
N year will mark 20 years since I developed a Southern blot showing altered DNA methylation in cancer. This discovery (1) was met with some skepticism, primarily because it was thought that aberrant methylation in cancer was an epiphenomenon, somehow linked to a generalized disruption of gene regulation in cancer cells and arising after the cancer, rather than playing a causal role itself. This...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.24.7215